Drug interactions and anti-infective therapies

Drug interactions are an important and often underappreciated cause of adve rse clinical outcomes. This review considers the mechanisms for several cli nically important drug interactions that involve the major classes of anti- infective agents. This approach is intended to complement the use of text-b ased references and computer databases so that physicians and pharmacists c an avoid prescribing and dispensing drugs that have adverse interactions. A m J Med. 1999; 106:227-237. (C) 1999 by Excerpta Medica, Inc.