J. Grill et al., Radiation-induced cerebral vasculopathy in children with neurofibromatosisand optic pathway glioma, ANN NEUROL, 45(3), 1999, pp. 393-396
Occlusive vasculopathy is a potential complication of radiotherapy in child
ren with optic pathway glioma. With a median follow-up of 7 years, 13 of 69
children in this study developed clinical and radiological signs of occlus
ive vasculopathy after radiotherapy within a median interval of 36 months.
The major risk factor was neurofibromatosis type 1. Radiotherapy should no
longer be the first treatment in these settings. When radiotherapy is unavo
idable, regular screening for cerebral vasculopathy is mandatory, as preven
tive treatment is available.