Monospecific anti-GD1b IgG is required to induce rabbit ataxic neuropathy

Authors
Kusunoki, S Hitoshi, S Kaida, K Arita, M Kanazawa, I
Citation
S. Kusunoki et al., Monospecific anti-GD1b IgG is required to induce rabbit ataxic neuropathy, ANN NEUROL, 45(3), 1999, pp. 400-403
Citations number
19
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
45
Issue
3
Year of publication
1999
Pages
400 - 403
Database
ISI
SICI code
0364-5134(199903)45:3<400:MAIIRT>2.0.ZU;2-7
Abstract
Of 22 rabbits sensitized with GD1b, 12 developed experimental sensory ataxi c neuropathy. The affected rabbits had a higher level of serum IgG monospec ific to GD1b than the unaffected ones. The GD1b-positiue neuronal cyoplasms of rabbit dorsal root ganglia had larger diameters than the negative ones. IgG antibody monospecific to GD1b may preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy.