AZT-5 '-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent

Authors
Jan, ST Zhu, Z Tai, HL Shih, MJ Venkatachalam, TK Uckun, FM
Citation
St. Jan et al., AZT-5 '-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent, ANTIVIR CHE, 10(1), 1999, pp. 47-52
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
ISSN journal
09563202 → ACNP
Volume
10
Issue
1
Year of publication
1999
Pages
47 - 52
Database
ISI
SICI code
0956-3202(199901)10:1<47:A'MPAA>2.0.ZU;2-L
Abstract
The potency and selectivity index of the AZT-phenyl phosphate derivatives i n thymidine kinase (TK)-deficient T cells were substantially enhanced by in troducing a single para-bromo substituent in the phenyl moiety. AZT-5'-(p-b romophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5'-( phenyl methoxyalaninyl phosphate) and was fivefold more potent than AZT in inhibiting human immunodeficiency virus (HIV) replication in TK-deficient C EM cells.