R. Hromas et al., Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells, BIOC BIOP R, 255(3), 1999, pp. 703-706
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Chemokines are a family of related proteins that regulate leukocyte infiltr
ation into inflamed tissue and play important roles in many disease process
es. Chemokines are divided into two major groups, CC or CXC, based on their
sequence around the amino terminal cysteines. We report the PCR cloning of
a novel human chemokine termed BRAK for its initial isolation from breast
and kidney cells. This novel chemokine is distantly related to other CXC ch
emokines (30% identity with MIP-2 alpha and beta) and shares several biolog
ical activities. BRAK is expressed ubiquitously and highly in normal tissue
. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is loca
ted on human chromosome 5q31. (C) 1999 Academic Press.