Synthesis and SAR of 2- and 3-substituted 7-azaindoles as potential dopamine D-4 ligands

Authors
Curtis, NR Kulagowski, JJ Leeson, PD Ridgill, MP Emms, F Freedman, SB Patel, S Patel, S
Citation
Nr. Curtis et al., Synthesis and SAR of 2- and 3-substituted 7-azaindoles as potential dopamine D-4 ligands, BIOORG MED, 9(4), 1999, pp. 585-588
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
585 - 588
Database
ISI
SICI code
0960-894X(19990222)9:4<585:SASO2A>2.0.ZU;2-E
Abstract
7-azaindole compounds bearing a cyclic amine moiety linked by a one or two carbon chain attached at the 2- or 3-position were synthesised and evaluate d as potential dopamine D-4 ligands. Highest affinity and selectivity for t he D-4 receptor resided in the 3-aminomethyl-7-azaindole series. (C) 1999 E lsevier Science Ltd. All rights reserved.