Sialidase inhibitors related to zanamivir: Synthesis and biological evaluation of 4H-pyran 6-ether and ketone

Authors
Smith, PW Robinson, JE Evans, DN Sollis, SL Howes, PD Trivedi, N Bethell, RC
Citation
Pw. Smith et al., Sialidase inhibitors related to zanamivir: Synthesis and biological evaluation of 4H-pyran 6-ether and ketone, BIOORG MED, 9(4), 1999, pp. 601-604
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
601 - 604
Database
ISI
SICI code
0960-894X(19990222)9:4<601:SIRTZS>2.0.ZU;2-R
Abstract
Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-(1-ethyl)propyl and 6R-(1- oxo-2-ethyl)butyl 2-carboxylic acids (4 and 5) and their evaluation as inhi bitors of influenza virus sialidase is described. Both compounds showed goo d inhibitory activity with marked selectivity for influenza A sialidase. (C ) 1999 Elsevier Science Ltd. All rights reserved.