Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase

Authors
Jones, PS Smith, PW Hardy, GW Howes, PD Upton, RJ Bethell, RC
Citation
Ps. Jones et al., Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase, BIOORG MED, 9(4), 1999, pp. 605-610
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
605 - 610
Database
ISI
SICI code
0960-894X(19990222)9:4<605:SOTBAP>2.0.ZU;2-H
Abstract
Several racemic bicyclo[3.2.1]octene derivatives have been synthesised and evaluated as inhibitors of influenza virus sialidases. The 5-acetamido-bicy clo [3.2.1]octenol 4 showed modest activity against influenza A and B virus sialidases. (C) 1999 Elsevier Science Ltd. All rights reserved.