Synthesis of a tetrasubstituted bicyclo[2.2.2]octane as a potential inhibitor of influenza virus sialidase

Authors
Smith, PW Trivedi, N Howes, PD Sollis, SL Rahim, G Bethell, RC Lynn, S
Citation
Pw. Smith et al., Synthesis of a tetrasubstituted bicyclo[2.2.2]octane as a potential inhibitor of influenza virus sialidase, BIOORG MED, 9(4), 1999, pp. 611-614
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
4
Year of publication
1999
Pages
611 - 614
Database
ISI
SICI code
0960-894X(19990222)9:4<611:SOATBA>2.0.ZU;2-R
Abstract
A novel synthesis of the bicycle [2.2.2] octane ring system has been achiev ed utilising a tandem Henry cyclisation as the key stage. This chemistry ha s been employed in the synthesis of a potential inhibitor of influenza viru s sialidase (C) 1999 Elsevier Science Ltd. All rights reserved.