Y. Yamamoto et al., Application of polymer supported base in solid phase synthesis: Convenientsynthesis of N-aryl-N '-benzyl piperazine derivatives, CHEM LETT, (2), 1999, pp. 103-104
N-Aryl-N'-benzyl piperazine derivatives were synthesized using REM resin. I
n cleavage step, the piperazine derivatives were successfully prepared in a
good yield and excellent purity by treatment with novel polymer supported
base in the absence of any base.