Organosulfur functionality as an alternative enantiocontrollable coordinating element in chiral phosphine ligands for palladium-catalyzed asymmetric allylic alkylations

The synthesis of (S)-proline-derived phosphines bearing organosulfur groups and the use of them as chiral ligands in palladium-catalyzed asymmetric al lylic alkylations were accomplished successfully. The mechanism is discusse d on the basis of the stereochemical results, presumably by participation o f organosulfur groups as alternative enantiocontrollable coordinating eleme nts.