Objective To create an arterial bifurcation aneurysm model in swine and eva
luate it with digital subtraction angiography (DSA).
Methods Ten swine were used for constructing the arterial bifurcation aneur
ysm models. Seven pigs underwent subsequent intraarterial DSA. Both surgica
l procedure and transarterial angiography were carried out under anesthesia
with mechanical ventilation after tracheal intubation.
Results Bifurcation aneurysms were surgically created in ten animals. After
surgical procedure, 2 pigs died from aneurysmal rupture and one died of an
esthetic overdose. DSA was performed in all other 7 animals and it demonstr
ated 6 patent aneurysms and one occluded. Three of the 6 patent bifurcation
aneurysms were wide-necked and 3 were narrow-necked.
Conclusion Arterial bifurcation aneurysm model can be successfully construc
ted in swine. It wilt provide us with an in vivo model to observe and devel
op therapeutic devices, teach endovascular techniques, and study aneurysmal
hemodynamics.