Swine model of arterial bifurcation aneurysm

Objective To create an arterial bifurcation aneurysm model in swine and eva luate it with digital subtraction angiography (DSA). Methods Ten swine were used for constructing the arterial bifurcation aneur ysm models. Seven pigs underwent subsequent intraarterial DSA. Both surgica l procedure and transarterial angiography were carried out under anesthesia with mechanical ventilation after tracheal intubation. Results Bifurcation aneurysms were surgically created in ten animals. After surgical procedure, 2 pigs died from aneurysmal rupture and one died of an esthetic overdose. DSA was performed in all other 7 animals and it demonstr ated 6 patent aneurysms and one occluded. Three of the 6 patent bifurcation aneurysms were wide-necked and 3 were narrow-necked. Conclusion Arterial bifurcation aneurysm model can be successfully construc ted in swine. It wilt provide us with an in vivo model to observe and devel op therapeutic devices, teach endovascular techniques, and study aneurysmal hemodynamics.