Cytokines and adhesion molecules in the course of acute myocardial infarction

Citation
R. Pudil et al., Cytokines and adhesion molecules in the course of acute myocardial infarction, CLIN CHIM A, 280(1-2), 1999, pp. 127-134
Citations number
15
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICA CHIMICA ACTA
ISSN journal
00098981 → ACNP
Volume
280
Issue
1-2
Year of publication
1999
Pages
127 - 134
Database
ISI
SICI code
0009-8981(199902)280:1-2<127:CAAMIT>2.0.ZU;2-W
Abstract
The plasma levels of interleukin 1 beta (IL 1 beta), interleukin 6 (IL 6), interleukin 8 (IL 8), tumor necrosis factor alpha (TNF-alpha), E-selectin, ICAM 1 and C-reactive protein (CRP) have been studied in 24 patients with a cute myocardial infarction in the course of 96 h. The plasma IL 1 beta and IL 6 levels were continually elevated during the 96 h study period (the pea k of plasma IL 1 beta level was 22.2 pg/ml, S.D. 8.6, P < 0.001, normal val ues of IL 1 beta are less than 10 pg/ml, the mean peak plasma concentration of IL 6 was 184.9 pg/ml, S.D. 134.7, vs, normal values of 15.57 pg/ml, S.D . 2.4, P < 0.001). The mean plasma IL 8 level was increased for the duratio n of the study, the mean plasma IL 8 level was 103.0 pg/ml, S.D. 23.4 (norm al value was below 30 pg/l, S.D. 8.0) P < 0.001. The plasma TNF-alpha level was elevated throughout the time of observation without any significant pe ak. The mean plasma TNF-alpha concentration was 46.8 pg/ml, S.D. 2.13, vs. normal value 4.35 pg/ml, S.D. 1.23, P < 0.001. The plasma E-selectin level reached the mean level of 145.1 ng/ml, S.D. 75.4, vs, normal value 29.1-63. 4 ng/ml, P < 0.001 at an interval of 15-42 h after the onset of the symptom s. The plasma ICAM 1 level showed only a slight significant increase during the first 36 h. The plasma CRP concentration increased later than IL 6, an d reached a peak at 42 h after the onset of the symptoms (69.2 mg/l, S.D. 2 9.9, vs. 1.2 mg/l, S.D. 4.7, P < 0.0001). We conclude that cytokines and ad hesion molecules can play an important role in the mechanisms of tissue inj ury in the process of ischemia and reperfusion. (C) 1999 Elsevier Science B .V. All rights reserved.