Antiarrhythmic drug therapy still remains the mainstay in the management of
many supraventricular and ventricular arrhythmias. Several studies have re
cently pointed out the role of orally administered class 1C drugs in termin
ating atrial fibrillation. These drugs can play an important role in the am
bulatory management of selected patients. The electrophysiologic mechanisms
of these antiarrhythmic drugs together with their pharmacologic properties
and clinical indications are discussed according to the current literature
.