Jt. Carstensen et M. Dali, Particle size distributions in mesh cuts and microscopically estimated volumetric shape factors, DRUG DEV IN, 25(3), 1999, pp. 347-352
When particle size distribution parameters are calculated from sieve analys
is, it is generally assumed that the distribution within the particle cut i
s either linear producing a mean particle size equal to the average of the
mesh openings (1-3), or that a more proper number is the geometric mean of
these two apertures. It is shown here that particles within a mesh cut are
not linearly distributed, but rather may be normally, log-normally or bipha
sic combinations of the two. Three compounds were examined in this fashion,
and results are reported here.