Lr. Angeletti et V. Gazzaniga, Hippocrates as endocrinologist? First observation of galactorrhea with amenorrhea in a nonpregnant woman (prolactinoma), ENDOCRINOLO, 9(1), 1999, pp. 53-55
The Hippocratic doctrine of the four humors and qualities has been assumed
as a precursor of modern endocrinology. There is a clinical endocrinologic
case in the Hippocratic Aphorism V, #39, probably describing the galactorrh
ea-amenorrhea syndrome in a nonpregnant woman. This Aphorism deserves parti
cular attention because it appears to be one of the first clear description
s of an endocrine syndrome.