Evidence of improving survival of patients with rectal cancer in France: apopulation based study

Background-Over the past 20 years there have been many changes in the manag ement of rectal cancer. Their impact on the overall population is not well known. Aims-To determine trends in management and prognosis of rectal cancer in tw o French regions. Subjects-1978 patients with a rectal carcinoma diagnosed between 1978 and 1 993. Methods-Time trends in treatment, stage at diagnosis, operative mortality, and survival were studied on a four year basis. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted f or the other variables. To estimate the independent effect of the period a multivariate relative survival analysis was performed. Results-Over the 16 year period resection rates increased from 66.0% to 80. 1%; the increase was particularly noticeable for sphincter saving procedure s (+30.6% per four years, (p = 0.03). The percentage of patients receiving adjuvant radiotherapy increased from 24.0% to 40.0% (p = 0.02). The proport ion of patients with Dukes) type A cancer increased from 17.7% to 30.6% wit h a corresponding decrease in those with more advanced disease. Operative m ortality decreased by 31.1% per four years (p = 0.03). All these improvemen ts have resulted in a dramatic increase in relative survival (from 35.4% fo r the 1978-1981 period to 57.0% for the 1985-1989 period). Conclusions-Substantial advances in the management of rectal cancer have be en achieved, but there is evidence that further improvements can be made in order to increase survival.