Turner's syndrome and pregnancies after oocyte donation

A total of 20 clinical pregnancies was achieved among 18 women with Turner' s syndrome who were treated in an oocyte donation programme. The oocytes we re donated by voluntary unpaid donors. A mean of 1.8 embryos per transfer w as given to each recipient by way of 28 fresh and 25 frozen embryo transfer s, With fresh and frozen embryos, 13 and seven pregnancies respectively wer e achieved. The clinical pregnancy rate per fresh embryo transfer was 46%, and the implantation rate 30%, being similar to the corresponding rates amo ng our oocyte recipients with primary ovarian failure in general. The corre sponding rates with frozen embryos were 28 and 19%. Of these pregnancies, 4 0% ended in miscarriage. This high rate may be explained by uterine factors . Six women were hypertensive during pregnancy, a rate comparable with that in other oocyte donation pregnancies. All these women delivered by Caesare an section. Pregnancy and implantation rates after oocyte donation were hig h in women with Turner's syndrome, but the risk of cardiovascular and other complications is high. Careful assessment before and during follow-up of p regnancy are important. Transfer of only one embryo at a time to avoid the additional complications caused by twin pregnancy is recommended.