Two approaches to the characterization of three-dimensional (3-D) textures
are presented: One based on gradient vectors and one on generalized co-occu
rrence matrices. They are investigated with the help of simulated data for
their behavior in the presence of noise and for various values of the param
eters they depend on. They are also applied to several medical volume image
s characterized by the presence of microtextures and their potential as dia
gnostic tools and tools for quantifying and monitoring the progress of vari
ous pathologies is discussed. No firm medical conclusions can be drawn as n
ot enough clinical data are available. The gradient based method appears to
be more appropriate for the characterization of microtextures. It also sho
ws more consistent behavior as a descriptor of pathologies than the general
ized co-occurrence matrix approach.