E. Campazzi et al., Organometallic radiopharmaceuticals: rhenium(I) carbonyl complexes of natural bile acids and derivatives, INORG CHIM, 286(1), 1999, pp. 46-54
The precursor [Re(CO)(3)(PPh3)(2)Cl] reacts with natural bile acids to give
new carboxylato-carbonyl(phosphine) rhenium(I) complexes [Re(CO)(2)(PPh3)(
2)(L)] (HL = natural bile acids). Coupling reactions between the carboxylic
group of bile acids with the NH2 moiety of 2-aminothiazole, 2-(2-aminoethy
l)pyridine and hydrazine form derivatives which coordinate the metal ion th
rough the deprotonated amidic group. For a comparison, the carboxylato-rhen
ium(I) complex [NEt4][Re(CO)(3)Cl(Ll)] (HLl = 3 alpha,7 alpha,12 alpha-trih
ydroxy-5 beta-cholic acid) was synthesized starting from the [Re(CO)(3)Cl-3
](2-) precursor. The complex [Tc(CO)(3)(PPh3)(2)Cl] reacts with HLl to form
the corresponding carboxylato-carbonyl compound [Tc(CO)(2)(PPh3)(2)(LI)].
No difference in reactivity is observed with respect to the reactions carri
ed out with the Re(I) starting materials. The complexes were characterized
by elemental analyses, IR and NMR spectral and a few also by mass spectrome
try. An octahedral geometry may be assigned to these complexes. The two pho
sphine ligands are located in the axial position, and the two cis-CO groups
having in trans the chelating ligand define the equatorial plane. (C) 1999
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