Translation initiation factor 4E

Authors
McKendrick, L Pain, VM Morley, SJ
Citation
L. Mckendrick et al., Translation initiation factor 4E, INT J BIO C, 31(1), 1999, pp. 31-35
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
ISSN journal
13572725 → ACNP
Volume
31
Issue
1
Year of publication
1999
Pages
31 - 35
Database
ISI
SICI code
1357-2725(199901)31:1<31:TIF4>2.0.ZU;2-2
Abstract
Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap st ructure of mRNA and mediates recruitment of mRNA to ribosomes, with the pot ential of regulating the overall rate of translation and discriminating bet ween different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogeni c Properties when overexpressed. The function of this review is to summaris e what is known about eIF4E gene and protein structure, biological function and medical relevance. (C) 1999 Elsevier Science Ltd. All rights reserved.