FEEDFORWARD CONTROL OF AGONIST-INDUCED CA2-KINASE-C IN AIRWAY SMOOTH-MUSCLE CELLS( SIGNALING BY PROTEIN)

Authors
HOITING BH KUIPERS R ELZINGA CRS ZAAGSMA J MEURS H
Citation
Bh. Hoiting et al., FEEDFORWARD CONTROL OF AGONIST-INDUCED CA2-KINASE-C IN AIRWAY SMOOTH-MUSCLE CELLS( SIGNALING BY PROTEIN), European journal of pharmacology. Molecular pharmacology section, 290(2), 1995, pp. 5-7
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology. Molecular pharmacology section → ACNP
ISSN journal
09224106
Volume
290
Issue
2
Year of publication
1995
Pages
5 - 7
Database
ISI
SICI code
0922-4106(1995)290:2<5:FCOACI>2.0.ZU;2-X
Abstract
In isolated bovine tracheal smooth muscle cells, the potent and specif ic protein kinase C inhibitor GF 109203X caused an inhibition of metha choline-and histamine-induced Ca2+ mobilization and influx, indicating for the first time that protein kinase C activation induced by contra ctile agonists exerts a positive feedforward control of Ca2+ signallin g by these agonists.