Mb. Mcdonald et al., Comparison of the effectiveness of 4 anti-inflammatory drops in relieving photophobia after pupil dilation, J CAT REF S, 25(3), 1999, pp. 405-410
Purpose: To compare the relative effectiveness of diclofenac, flurbiprofen,
ketorolac, and prednisolone acetate in relieving photophobia after pupil d
ilation for fundus examination.
Setting: Eye, Ear, Nose, and Throat Hospital, New Orleans, Louisiana, USA.
Methods: This prospective, blind, placebo-controlled study comprised 105 pa
tients randomly assigned to 1 of 10 treatment groups. Five minutes after in
stillation of dilating drops, each patient received drops of different test
medications in the right and left eyes. Light sensitivity and pupil measur
ement tests were performed over 2 hours after the pharmacological mydriasis
. After photostimulation, patients were asked to rate their photosensitivit
y on numerical and analog scales and to indicate a filter value required to
alleviate light-induced discomfort. Test results were analyzed to detect d
ifferences among the pain levels associated with each treatment.
Results: There were no significant differences between the placebo and any
active I treatment drug at any time during the study.
Conclusion: These findings suggest that mediators other than prostaglandins
may have a role in photosensitivity or that increased postmydriatic photos
ensitivity is a result of higher light levels entering the eye through the
dilated pupil.