Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1

Authors
Gruffat, H Portes-Sentis, S Sergeant, A Manet, E
Citation
H. Gruffat et al., Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1, J GEN VIROL, 80, 1999, pp. 557-561
Citations number
35
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF GENERAL VIROLOGY
ISSN journal
00221317 → ACNP
Volume
80
Year of publication
1999
Part
3
Pages
557 - 561
Database
ISI
SICI code
0022-1317(199903)80:<557:KSH(HE>2.0.ZU;2-L
Abstract
Analysis of the recently completed genomic sequence of Kaposi's sarcoma-ass ociated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a pr otein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein t hat has homology to the EBV transcription factor EB1. The newly characteriz ed K8 protein forms homodimers but does not heterodimerize with other membe rs of the bZip protein family.