SYNTHESIS OF METABOLITES OF THE CEREBROPROTECTING AGENT PIPERAZINYL]ACETYL]AMINO]-2,2,4,6-TETRAMETHYLINDAN (OPC-14117)

Authors
OTSUBO K MATSUBARA J KITANO K KAWANO Y OHTANI T MORITA S SATO S OSHIRO Y UCHIDA M
Citation
K. Otsubo et al., SYNTHESIS OF METABOLITES OF THE CEREBROPROTECTING AGENT PIPERAZINYL]ACETYL]AMINO]-2,2,4,6-TETRAMETHYLINDAN (OPC-14117), Chemical and Pharmaceutical Bulletin, 45(4), 1997, pp. 728-732
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
4
Year of publication
1997
Pages
728 - 732
Database
ISI
SICI code
0009-2363(1997)45:4<728:SOMOTC>2.0.ZU;2-J
Abstract
A hydroxylated metabolite (5a) of 7-hydroxy-1-[[[4-(3-methoxyphenyl)-1 -piperazinyl acetyl]amino]-2,2,4,6-tetramethylindan (OPC-14117), which is a novel cerebroprotective agent with central nervous system-stimul ating activity, was synthesized by use of a model cytochrome P-450 sys tem. In order to confirm the structure of this compound it was prepare d by another route. The structures of several metabolites (5a, 7 and 8 ) were identified by means of comparisons with the synthetic compounds .