ABSOLUTE STEREOSTRUCTURES OF ALISMALACTONE 23-ACETATE AND ALISMAKETONE-A 23-ACETATE, NEW SECO-PROTOSTANE AND PROTOSTANE-TYPE TRITERPENES WITH VASORELAXANT EFFECTS FROM CHINESE ALISMATIS RHIZOMA

Authors
YOSHIKAWA M MURAKAMI T IKEBATA A ISHIKADO A MURAKAMI N YAMAHARA J MATSUDA H
Citation
M. Yoshikawa et al., ABSOLUTE STEREOSTRUCTURES OF ALISMALACTONE 23-ACETATE AND ALISMAKETONE-A 23-ACETATE, NEW SECO-PROTOSTANE AND PROTOSTANE-TYPE TRITERPENES WITH VASORELAXANT EFFECTS FROM CHINESE ALISMATIS RHIZOMA, Chemical and Pharmaceutical Bulletin, 45(4), 1997, pp. 756-758
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
4
Year of publication
1997
Pages
756 - 758
Database
ISI
SICI code
0009-2363(1997)45:4<756:ASOA2A>2.0.ZU;2-H
Abstract
New bioactive seco-protostane and protostane-type triterpenes, alismal actone 23-acetate and alismaketone-A 23-acetate, were isolated from Ch inese Alismatis Rhizoma originating from Fukien province, the dried rh izoma of Alisma orientale JUZEP. Absolute stereostructures of the new triterpenes were determined on the basis of chemical and physicochemic al evidence, which included chemical correlations with the known trite rpene alisol B monoacetate. Alismalactone W-acetate and alismaketone-A 23-acetate were found to show inhibitory activity on the contractions induced by a high concentration of K+ in isolated aortic strips from rats.