Paclitaxel analogues from Taxus x media cv. Hicksii

Authors
Gabetta, B Fuzzati, N Orsini, P Peterlongo, F Appendino, G Vander Velde, DG
Citation
B. Gabetta et al., Paclitaxel analogues from Taxus x media cv. Hicksii, J NAT PROD, 62(2), 1999, pp. 219-223
Citations number
32
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
219 - 223
Database
ISI
SICI code
0163-3864(199902)62:2<219:PAFTXM>2.0.ZU;2-G
Abstract
The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of pac litaxel modified at the N-acyl residue (N-debenzoyl-N-alpha-methylbutyryl p aclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, Ib and Ic, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, Id). Compou nds Pb and Id showed reduced cytotoxicity and tubulin binding compared to p aclitaxel, while Ic retained substantial activity in these assays.