Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens

Authors
Neve, J Leone, PD Carroll, AR Moni, RW Paczkowski, NJ Pierens, G Bjorquist, P Deinum, J Ehnebom, J Inghardt, T Guymer, G Grimshaw, P Quinn, RJ
Citation
J. Neve et al., Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens, J NAT PROD, 62(2), 1999, pp. 324-326
Citations number
8
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
324 - 326
Database
ISI
SICI code
0163-3864(199902)62:2<324:SCANIO>2.0.ZU;2-3
Abstract
Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flow ers of Eucalyptus albens through bioassay-guided fractionation. The structu re elucidation was based on 1D and 2D NMR experiments, MS analysis, and com parison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited huma n plasminogen activator inhibitor type-1 at 4.7 mu M without any significan t effect on human tissue plasminogen activator.