Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

Authors
Isaka, M Punya, J Lertwerawat, Y Tanticharoen, M Thebtaranonth, Y
Citation
M. Isaka et al., Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria, J NAT PROD, 62(2), 1999, pp. 329-331
Citations number
17
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
329 - 331
Database
ISI
SICI code
0163-3864(199902)62:2<329:AAOMTI>2.0.ZU;2-I
Abstract
Bioassay-guided fractionation of an extract from the fungus Myrothecium ver rucaria BCC 112 resulted in the first isolation of roridin E acetate (5) fr om nature together with four common macrocyclic trichothecene isomers (1-4) . Trichothecenes 1-5, while known as mycotoxins, were evaluated for their h igh antimalarial activity.