Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana

Authors
Carney, JR Krenisky, JM Williamson, RT Luo, J Carlson, TJ Hsu, VL Moswa, JL
Citation
Jr. Carney et al., Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana, J NAT PROD, 62(2), 1999, pp. 345-347
Citations number
21
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
345 - 347
Database
ISI
SICI code
0163-3864(199902)62:2<345:MANDDW>2.0.ZU;2-6
Abstract
Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Co mpound 2 showed potent glucose-lowering properties when given by the oral r oute.