8-methyl-pyridoxatin: A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells

Authors
Cai, P Smith, D Cunningham, B Brown-Shimer, S Katz, B Pearce, C Venables, D Houck, D
Citation
P. Cai et al., 8-methyl-pyridoxatin: A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells, J NAT PROD, 62(2), 1999, pp. 397-399
Citations number
8
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
397 - 399
Database
ISI
SICI code
0163-3864(199902)62:2<397:8ANNPF>2.0.ZU;2-C
Abstract
In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive H-1 and C-13 NMR spect roscopic and chemical studies. This compound induced erythropoietin gene ex pression fivefold at a concentration of 0.3 mu M, which is about threefold greater potency than our previously identified erythropoietin inducers.