Effect of acute and chronic administration of dehydroepiandrosterone on(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced wet dog shaking behavior in rats
M. Inagaki et al., Effect of acute and chronic administration of dehydroepiandrosterone on(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced wet dog shaking behavior in rats, J NEURAL TR, 106(1), 1999, pp. 23-33
It has been reported that dehydroepiandrosterone (DHEA) or dehydroepiandros
terone sulfate (DHEA-S) is associated with affective disorders and that pat
hology of affective disorders are related with dysfunction of serotonin(S-H
T)-2A receptor-mediated responses. In this study, we investigated the effec
t of DHEA on (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI), 5-H
T-2A receptor agonist, -induced wet dog shaking behavior (WDS) in rats.
Acute treatment with DHEA inhibited the DOI-induced WDSs dose dependently.
This inhibition was recovered by opioid receptor antagonist, naltrexone. 5-
HT-2A receptor-mediated WDSs were desensitized after chronic treatment with
DOI, however chronic treatment with DHEA had no effect on this desensitiza
tion.
Chronic treatment with DHEA had no facilitating effect of chronic dexametha
sone treatment on DOI-induced WDSs.
These findings may lead the possibility that DHEA has the inhibitory effect
of 5-HT-2A mediated signaling pathway via non-genomic action.