S. Mori et al., The effect of diabetes mellitus on histopathological changes in the denture-supporting tissues under continuous mechanical pressure in rat, J ORAL REH, 26(1), 1999, pp. 80-90
The histopathological changes in denture-supporting tissues of streptozotoc
in-induced diabetes mellitus rat were studied in relation to continuous mec
hanical pressure exerted through an experimental denture base. The experime
ntal dentures were designed to load continuous mechanical pressures (3.4, 1
.5 or 0.5 kPa) to the hard palate of the molar region of a rat. From the re
sults of this study, the following conclusions were drawn: the streptozotoc
in-induced diabetic condition(1) tended to prolong the appearance period of
a shortened epithelial ridge, and weakened the phenomenon, (2) reduced the
appearance period and severity of the compression of epithelium, (3) delay
ed the time of manifestation of the proliferative change in the recovery pr
ocess of the shortened epithelial ridge, and weakened the phenomenon, (4) p
rolonged the appearance period of the compressed lamina propria mucosae, an
d enhanced the phenomenon, (5) reduced the number of osteoclasts, (6) lower
ed the threshold for induction of the osteoclastic bone resorption to betwe
en 1.5 and 0.5 kPa, (7) inhibited the appearance of osteoblast which follow
s the disappearance of osteoclasts, (8) did not induce any inflammatory cha
nge, and (9) tended to enhance the longitudinal change of the continuous me
chanical pressure. The histopathological changes in the denture-supporting
tissues of the streptozotocin-induced diabetes mellitus rat related highly
to the longitudinal change of the continuous mechanical pressure exerted th
rough the denture base. From the results of this study, it was suggested th
at the streptozotocin-induced diabetic condition lowers the tolerance of th
e denture-supporting tissues to continuous mechanical pressure.