Chronic idiopathic urticaria: Comparison of the clinical features of patients with and without anti-Fc epsilon RI or anti-IgE autoantibodies

Background: Previous studies defining the clinical features of patients wit h chronic idiopathic urticaria (CIU) were performed before the identificati on of functional autoantibodies against Fc epsilon RI and/or IgE, now known to be present in approximately 30% of patients with CIU. Objective: Our purpose was to determine whether there are differences betwe en patients with and those without autoantibodies in the clinical features or severity of CIU. Methods: The clinical features of 107 patients with CIU were evaluated pros pectively. Patients were identified as having functional autoantibodies on the basis of the serum-evoked histamine release in vitro from the basophils of 2 healthy donors. Results: Patients with autoantibodies (31%) had more wheals (P =.005), a wi der distribution of wheals (P =.009), higher itch scores for the most sever e episodes of itching (P =.002), more systemic symptoms (P =.03), and lower serum IgE levels (P <.0005) than patients without autoantibodies. Conclusion: The presence of autoantibodies indicates a subset of patients w ith more severe CIU.