Reaction of 4-aryl-3-thiosemicarbazides with phenylisothiocyanate: A facile synthesis of thiazole, pyrazole and pyrimidine derivatives

Authors
Wardakhan, WW Fleita, DH Mohareb, RM
Citation
Ww. Wardakhan et al., Reaction of 4-aryl-3-thiosemicarbazides with phenylisothiocyanate: A facile synthesis of thiazole, pyrazole and pyrimidine derivatives, J CHIN CHEM, 46(1), 1999, pp. 97-104
Citations number
12
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
46
Issue
1
Year of publication
1999
Pages
97 - 104
Database
ISI
SICI code
0009-4536(199902)46:1<97:RO4WPA>2.0.ZU;2-L
Abstract
The reaction of 4-aryl-3-thiosemicarbazides 1a-d with phenylisothiocyanate gave the intermediate potasium salts 2a-d. The latter afforded 3a-d, 13a-d and 19 upon the reaction with phenacyl bromide, monochloroacetic acid and e thyl bromocyanoacetate respectively.