Citation
Wf. Chen et al., Alcalase-catalyzed synthesis of novel 2,6-dimethoxyhydroquinone-3-mercaptoacetyl-peptide conjugates, J CHIN CHEM, 46(1), 1999, pp. 127-129
Citations number
9
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536
→ ACNP
Volume
46
Issue
1
Year of publication
1999
Pages
127 - 129
Database
ISI
SICI code
0009-4536(199902)46:1<127:ASON2>2.0.ZU;2-B
Abstract
Seven dipeptide and one tripeptide conjugates of the cytotoxic drug 2,6-dim
ethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA) conjugates were prepared
successfully by an alcalase-catalyzed reaction in alcohols, using DMQ-MA-X-
OMe as the acyl donor and H2N-Y-CONH2 as the nucleophile (where X and Y are
amino acids, and amino acid/dipeptides, respectively).