Amplification of the c-yes oncogene in canine mammary tumors

Authors
Rungsipipat, A Tateyama, S Yamaguchi, R Uchida, K Murakami, Y Miyoshi, N Hayashi, T
Citation
A. Rungsipipat et al., Amplification of the c-yes oncogene in canine mammary tumors, J VET MED S, 61(2), 1999, pp. 185-189
Citations number
28
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY MEDICAL SCIENCE
ISSN journal
09167250 → ACNP
Volume
61
Issue
2
Year of publication
1999
Pages
185 - 189
Database
ISI
SICI code
0916-7250(199902)61:2<185:AOTCOI>2.0.ZU;2-5
Abstract
Genomic DNAs of 14 mammary tumors were analyzed by Southern blot hybridizat ion using a human c-yes-1 oncogene probe. The amplification was successful in half of the cases (7 adenocarcinomas). The degree of amplification was a pproximately 4-fold, and a high proportion was seen in malignant tumors. In addition, DNA polymorphism was detected in two adenocarcinomas.