A HUMAN HOMOLOG OF THE VACCINIA VIRUS HINDIII K4L GENE IS A MEMBER OFTHE PHOSPHOLIPASE-D SUPERFAMILY

Authors
CAO JX KOOP BF UPTON C
Citation
Jx. Cao et al., A HUMAN HOMOLOG OF THE VACCINIA VIRUS HINDIII K4L GENE IS A MEMBER OFTHE PHOSPHOLIPASE-D SUPERFAMILY, Virus research, 48(1), 1997, pp. 11-18
Citations number
55
Categorie Soggetti
Virology
Journal title
Virus research → ACNP
ISSN journal
01681702
Volume
48
Issue
1
Year of publication
1997
Pages
11 - 18
Database
ISI
SICI code
0168-1702(1997)48:1<11:AHHOTV>2.0.ZU;2-P
Abstract
We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain mo tifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia virus p37, encoded by the F13L gene, which is required for envelopment and spread of the virus. The similarity to phospholipase D provides insight into the mechanisms and evolution of these processes. (C) 1997 Elsevier Science B.V.