Chromosomal localization of three human genes encoding bone morphogenetic protein receptors

Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily that play a pivotal role in bone formation during embryogenesis and fractur e repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinas e complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR- II). BMPR-IA and IB are closely related receptors, with sequence difference s conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromoso mal localization of all three BMPR genes. Using somatic cell hybrid and FIS H analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q2 2-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped t o 6q23.