SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF A NEW TC-99M COMPLEX WITH TRIMETHYLSILYLMETHYLISONITRILE - COMPARISON WITH TC-99M-TBI AND TC-99M-MIBI

An isonitrile ligand with a silicium component was synthesized and a c opper salt of this ligand was then used to form a Tc-99m complex. We e valuated the physicochemical characteristics of the complex and its bi odistribution in rat. The chemical properties, i.e. lipophilic affinit y and charge, were comparable to those of other Tc-99m complexes forme d with similar isonitrile compounds (Tc-99m-MIBI and Tc-99m-TBI). In c ontrast, the tissue biodistribution of this new technetium complex dif fered markedly, as it was mainly taken up in the liver and not at all in the heart.