EFFECTS OF BETAMIPRON ON CISPLATIN NEPHROTOXICITY AND ITS PHARMACOKINETICS IN RATS

The protective effects of betamipron (BP, N-benzoyl-beta-alanine) on t ile nephrotoxicity of cisplatin were examined as indicated by body wei ght gain, ratio of kidney weight to body weight, blood urea nitrogen a nd serum creatinine levels in tumor-bearing rats. The results showed c learly that administration of BP Ih after cisplatin treatment affords protection against the nephrotoxicity of cisplatin. Furthermore, the a ddition of BP to cisplatin had no apparent effect on the efficacy of c isplatin against Walker 256 carcinosarcoma cells in rats, In addition, no observed significant difference in plasma cisplatin concentration between cisplatin with alkaline solution and cisplatin with BP mag be partly attributed to the decrease in the cisplatin er;sorption to the intestine and its excretion to bile, and to an increase in cisplatin e xcretion to the urine.