Surfactant replacement therapy for respiratory distress syndrome

Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in low birth weight immature infants. Surfactant th erapy substantially reduces mortality and respiratory morbidity for this po pulation. The statement summarizes the indications for surfactant replaceme nt therapy. Because respiratory insufficiency may be a component of multior gan dysfunction in sick infants, surfactant should be administered only at institutions with qualified personnel and facilities for the comprehensive care of sick infants.