Standard lattice fermion algorithms run into the well-known sign problem wi
th a real chemical potential. In this paper we investigate the possibility
of using an imaginary chemical potential and argue that it has advantages o
ver other methods, particularly for probing the physics at finite temperatu
re as well as density. As a feasibility study, we present numerical results
for the partition function of the two-dimensional Hubbard model with an im
aginary chemical potential. We also note that systems with a net imbalance
of isospin may be simulated using a real chemical potential that couples to
I-3 without suffering from the sign problem. [S0556-2821(99)05203-0].