R. Tabakovic et I. Tabakovic, Catalysis of nifuroxazide formation by crosslinked poly(vinylpyridine)-supported acids, REACT FUNCT, 39(3), 1999, pp. 263-268
The condensation reaction of either 5-nitrofuran-2-aldehyde (NFA) or 5-nitr
ofuran-2-aldehyde diacetate (NFAD) with p-hydroxybenzalhydrazide (PHBH) gav
e nifuroxazide (NF), a drug used for the treatment of acute bacterial diarr
hea, by catalysis with crosslinked poly(vinylpyridine)-supported acids (PVP
HX). The product NF was obtained with high yield and purity. The effects of
the counteranion, X-, in polymer catalyst (PVPHX) on the rate of the react
ion were studied. It was found that the catalytic activity is increasing in
order: I- > ClO4-, Cl- = Br- > TsO-. The effects of temperature and amount
of catalyst on the reaction rate were discussed. (C) 1999 Published by Els
evier Science B.V. All rights reserved.