S. Rozenberg et al., Efficacy of epidural steroids in low back pain and sciatica - A critical appraisal by a French task force of randomized trials, REV RHUM, 66(2), 1999, pp. 79-85
Objective. Several randomized trials have suggested recently that epidural
steroid injections may not be a valid treatment in common low back pain and
sciatica, To clarify this issue, we conducted a critical appraisal of rele
vant randomized trials published up to 1997. Attention was directed to meth
odological quality. results, and clinical implications. Method. A Medline s
earch identified 13 trials published between 1966 and 1997. Trial methodolo
gy was evaluated using a 100-point grid based on four groups of items, name
ly study population, therapeutic intervention, evaluation method, and data
presentation and analysis. Results. Methodology quality scores ranged from
12 to 84 and were unrelated to the results of epidural steroid therapy. Fiv
e trials demonstrated greater pain relief within the first month in the ste
roid group as compared to the control group. Fight trials found no measurab
le benefits. Obstacles to meaningful comparisons across studies included di
fferences in the patient populations, steroid used, volume injected. and nu
mber of injections. None of the published studies used the injection modali
ties that are standard practice in France. Conclusion. Whether epidural ste
roids are effective in common low back pain and sciatica cannot be determin
ed based on our review.