Although its overall prevalence is decreasing, leprosy continues to be a ma
jor cause of neuropathy worldwide. In the United States, it is a relatively
rare condition. As a result, physicians may lack familiarity with the dise
ase, which can delay diagnosis and treatment. Leprous neuropathy is charact
erized by involvement of dermal nerves and superficial peripheral nerve tru
nks in cooler body regions. A continuing pattern of immigration from endemi
c areas may allow practicing neurologists in any region of the country to b
ecome involved in the care of patients with leprosy. The diagnosis should b
e considered in patients from endemic regions presenting with peripheral ne
uropathy with or without skin lesions. Readily available diagnostic testing
, access to subspecialists, and modern transportation and information syste
ms through the satellite clinics of the Hansen's Disease Center serve as ma
jor advantages for the management of leprosy patients in the United States.