OCULAR MANIFESTATIONS OF FAMILIAL AMYLOIDOTIC POLYNEUROPATHY TYPE-I -LONG-TERM FOLLOW-UP

Citation
E. Ando et al., OCULAR MANIFESTATIONS OF FAMILIAL AMYLOIDOTIC POLYNEUROPATHY TYPE-I -LONG-TERM FOLLOW-UP, British journal of ophthalmology, 81(4), 1997, pp. 295-298
Citations number
21
Categorie Soggetti
Ophthalmology
ISSN journal
00071161
Volume
81
Issue
4
Year of publication
1997
Pages
295 - 298
Database
ISI
SICI code
0007-1161(1997)81:4<295:OMOFAP>2.0.ZU;2-Q
Abstract
Aims-To obtain precise information on ocular manifestations of familia l amyloidotic polyneuropathy (FAP) type I, the incidence of five main ocular manifestations-abnormal conjunctival vessels (ACV), keratoconju nctivitis sicca (KCS), pupillary abnormality, vitreous opacity, and gl aucoma, were compared through long term follow up. Methods-Ocular exam inations were performed in 37 FAP type I patients (Met30) from once to 12 times over a period of 1 to 12 years and 7 months. Results-The fol lowing incidences were observed on initial examination of each patient with FAP: ACV in 75.5%, pupillary abnormalities in 43.2%, KCS in 40.5 %, glaucoma in 5.4%, and vitreous opacity in 5.4%. All ocular manifest ations increased with the progression of FAP, and the incidence of ACV reached 100% during follow up: this may be helpful in the diagnosis o f FAP. Conclusion-Since no precise statistical ocular study on FAP wit h long term follow up has been performed, this report may provide impo rtant information to help elucidate the mechanism of the amyloid distr ibuting process in the amyloid targeted organs of FAP and to provide t he natural course of ocular manifestations of FAP.