Combination of the metabolic syndrome components in patients with arterialhypertension and their relationship with dyslipidemia

Aim. To detect the correlation between complete metabolic syndrome (MS) and combinations of arterial hypertension (AP) with abdominal obesity (AO), hy perlipidemia (HLP), and both without disorders in glucose tolerance. Materials and methods. 122 men aged 35-66 years were examined, in whom AP w as diagnosed 4-6 years before. The following criteria were used for detecti ng MS components: AP was diagnosed at diastolic AP of at least 90 mm Hg or systolic AP of 140 mm Hg; HLP was confirmed at total cholesterol (CS) level of at least 5.2 mmol/liter and/or triglyceride (TG) level of at least 2.3 mmol/liter; AO was diagnosed at body weight index of at least 26 kg/m(2) an d the ratio of waist/hip circumferences more than 0.90. Poor glucose tolera nce was diagnosed at glucose level in capillary blood 120 mg/dl and higher, but no more than 180 mg/dl 2 h after 75 g glucose loading, if glucose leve l after an overnight fasting was no higher than 120 mg/dl. Results. The majority of patients (39.3%) had combinations of AP with AO an d HLP; complete MS was diagnosed in 21%. Isolated AP was found in only 8.2% of examinees. Dyslipidemia in the presence of MS and in combinations of AP with AO and HLP was characterized by increased levels of TG and total CS a nd decreased content of CS and high-density lipoproteins, which was associa ted with basal hyperinsulinemia. Conclusion. MS alone and clusters of AP, AO, and HLP characterized by insul in resistance, accelerate the development of cardiovascular diseases associ ated with atherosclerosis.