Integrated chemical process. Construction of highly substituted allylic moieties from allylic sulfones in one-pot

According to "integrated chemical process", a novel one-pot process for con struction of highly substituted allylic moieties has been achieved. A serie s of alkylation of allylic sulfones and palladium-catalyzed reductive desul fonylation by use of LiBHEt3 is integrated. The double alkylation furnishes more substituted olefins. Use of arylzinc compounds in place of the hydrid e enables electrophilic alkylation/nucleophilic arylation in one-pot. The i ntegrated process provides higher overall yields than the corresponding ste pwise process. (C) 1999 Elsevier Science Ltd. All rights reserved.