A practical synthesis of the modified RNA nucleoside pseudouridine

Authors
Grohar, PJ Chow, CS
Citation
Pj. Grohar et Cs. Chow, A practical synthesis of the modified RNA nucleoside pseudouridine, TETRAHEDR L, 40(11), 1999, pp. 2049-2052
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
11
Year of publication
1999
Pages
2049 - 2052
Database
ISI
SICI code
0040-4039(19990312)40:11<2049:APSOTM>2.0.ZU;2-X
Abstract
An alternative synthesis of the modified RNA nucleoside pseudouridine is re ported. This procedure employs coupling of an iodinated pyrimidine and a su itably protected lactone. The resulting hemiacetal is reduced and deprotect ed to yield pseudouridine. (C) 1999 Elsevier Science Ltd. All rights reserv ed.